SDCBP and colorectal carcinoma: Another study demonstrated that PGE2 release induced by chemotherapy promoted neighbouring CSC repopulation, and that this repopulation could be abrogated by celecoxib-mediated blockade of PGE2 signalling.36 The most meaningful finding in our present study was that under syntenin-1-expressing conditions, CRC cell lines showed changes in L-OHP chemosensitivity and CSCs upon loading with prostaglandins or suppression by celecoxib.