SDCBP and neoplasm: Melanoma differentiation-associated gene-9, also known as syntenin-1, is a multifunctional scaffold protein that cross-talks with different classes of proteins and activates defined cell signalling pathways, thus regulating diverse physiologic and pathologic processes, including tumour progression and metastasis.12,13 Syntenin-1 reportedly links activated leucocyte cell adhesion molecule to the actin cytoskeleton in the dendritic cells, which play a key role in the immunoregulation.14 Syntenin-1 also plays critical roles in regulating various other forms of immunomodulation.15–22