Potentially informative examples in lenient blocks include rs2427290 linked to colorectal cancer via GWAS peak SNP rs4925386 (nearest genes OSBPL2, ADRM1, MIR4758, LAMA5, RPS21, CABLES2; Additional file 2: Figure S8) and rs2283639 linked to non-small cell lung cancer via GWAS peak SNP rs1209950 (nearest genes LINC00114, ETS2, LOC101928398; Additional file 2: Figure S9). The gene discussed is RPS21; the disease is colorectal cancer.