To more completely understand the features of ASM in cancers, and to further test the hypothesis that destructive SNPs in TF binding motifs give rise to ASM, we searched for somatic mutations in the 4 multiple myeloma cases that were paired with non-neoplastic peripheral blood B cells from the same patients (analyzed using the same WGBS library protocol to ensure similar regional coverage depth) which served as germline reference sequences. Here, TF is linked to cancer.