A promising example in a non-neoplastic disease is provided by ASM index SNP rs2664280, which disrupts multiple ASM-enriched and ASM-correlated JUNB and AP1 binding motifs (all with greater predicted binding affinity on the REF allele) and is in strong LD with a GWAS peak SNP for psoriasis (Fig. 7). Here, JUNB is linked to psoriasis.