A plasmid DNA vaccine encoding mycobacterial heat shock protein 65 (Hsp65) and interleukin‐12 (IL‐12), delivered by the hemagglutinating virus of Japan (HVJ) envelope (E) in liposomes,181 induced protective as well as therapeutic efficacy against drug resistant TB in murine models in combination with anti‐tuberculous drugs.182, 183. Here, HSPD1 is linked to tuberculosis.