Besides their “help” to CD8+ T cell responses, CD4+ T cells can mediate other anti‐tumor effects such as direct killing of tumor cells, recruitment toward and activation of innate immune cells (eg, NK cells or M1 macrophages) at the tumor site, and modulation of the tumor microenvironment by anti‐angiogenic effects.139, 140. The gene discussed is CD8A; the disease is neoplasm.