ESR2, like ESR1, contains multiple polymorphisms that have been implicated in diseases related to old age and reproduction, as related to bone mineral density (Ichikawa et al., 2005), cancers of the breast and ovary (Tang et al., 2018; Yu et al., 2011) and hypertension and cardiovascular risk (Ogawa et al., 2000; Rexrode et al., 2007). This evidence concerns the gene ESR1 and breast carcinoma.