We further validated 13 out of 75 MYC target genes ARMC6, BEND4, C12orf66, CAMKV, CLCN2, DCTPP1, EIF4G1, ELOVL6, FBL, HSPE1, JPH1, LIG3 and PRMT1 which were up-regulated in MYCN amplified neuroblastoma tissues in GSE19274 and GSE85047 datasets (Fig. 2b). This evidence concerns the gene LIG3 and neuroblastoma.