SEMA6A and Duchenne muscular dystrophy: In contrast, serum semaphorin-6A protein levels showed no univariate correlation with TTSTAND clinical outcome (despite strong multivariate LASSO signal) but showed very strong upregulation of its mRNA in DMD muscle (−2.9-fold in normal muscle) and correlation with histological severity (r = −0.5; adjusted P = 0.023).