The Cip/Kip family could be inactivated by this pathway as reported in MCF-7 breast cancer (Varshochi et al., 2005), pancreatic cancer (Jiao et al., 2014), colon cancer (Chen et al., 2009), thyroid cancer (Weinlander et al., 2014), and gastric cancer (Sun et al., 2014). Here, CIB1 is linked to malignant colon neoplasm.