Previously, we reported the effect of DNA demethylating agent 5-aza-2′-deoxycytidine (decitabine, 5AZA-CdR) and histone deacetylase inhibitors valproic acid (VPA) and trichostatin A (TSA) on histone deacetylase 1, DNA methyltransferase 1, and Cip/Kip family (p21, p27, and p57) genes expression, cell growth inhibition, and apoptosis induction in colon cancer SW480 cell line (Sanaei et al., 2018). This evidence concerns the gene CDKN1A and colonic neoplasm.