They inhibit Class I (HDAC1, 2, 3, and 8) and class II HDACs (HDAC4, 5, 6, 7, 9, and 10) in various cancers including colon cancer, lung cancer, breast cancer, gastric cancer, and pancreatic cancer cells (Chueh et al., 2015). The gene discussed is HDAC1; the disease is malignant colon neoplasm.