As we reported, other studies have been demonstrated that TSA up-regulates p21Cip1/Waf1/Sdi1 in colon cancer SW480 and HT-29 cell lines (Spurling et al., 2008), p27Kip1 in colon cancer HT-29 M6 (Mayo et al., 2007). The gene discussed is CDKN1B; the disease is malignant colon neoplasm.