AKT1 and neoplasm: EGFR activation triggers two primary intracellular signaling pathways, such as Ras/Raf/MAPK and the PI3K/Akt pathways, which enhances survival proliferation, migration and apoptosis resistance of certain tumor cells (Liu et al., 2018b; Sigismund et al., 2018; Singh and Jadhav, 2018).