PKIB and cancer: PKIB promoted cell proliferation (Dou et al., 2016), while slight down-regulation of it appeared in the HCT116-CSCs which might participate in the feature of cancer stem cells, but their expression greatly reduced in the HCT116-BR cells It is possible that a decrease in the PKIB expression is a strategy to reduce cell activity and preserve energy for the survival of CSCs and the downregulation in HCT116-BR cells, may decrease in response to butyrate-induced apoptosis, which leads to butyrate resistance, while LOC399959 is a non-coding RNA, whose function in cancer is still unknown.