miR-613 could inhibit cancer cell proliferation, migration, invasion and promotes apoptosis by targeting numerous oncogenes, including DCLK1 (Wang et al., 2016), Fzd7 (Ren et al., 2016), and SphK2 (Qiu et al., 2016).miR-613 had been stated to be down-regulated in different cancers and act as a tumor suppressor (Wang et al., 2016). Here, SPHK2 is linked to cancer.