TNF-α is implicated in intestinal metaplasia and hyperplastic gastric tumors (Oshima et al., 2005; Senthilkumar et al., 2011), through the stimulation of some proteins expression required in the development of intestinal cell, such as CDX1 and CDX2, intestinal mucin MUC2 and MUC4 (Ahn et al., 2005; Coskun et al., 2011; Mejías-Luque et al., 2010). The gene discussed is MUC4; the disease is gastric neoplasm.