Topical simulation and screening of the mutations introduced a gene named HPC2/ELAC2 as suppressor of prostate cancer which this gene possesses the hazardous mutations related to relational prostate cancer (Wang et al., 2001) ELAC2 protein is an enzyme on phosphodiesterase encoded by ELAC2 gene in human (Rebbeck et al., 2000; Noda et al., 2006). The gene discussed is ELAC2; the disease is Familial prostate cancer.