ELAC2 and Familial prostate cancer: In his study, Dong showed that two prevalent Missense variants of Ser217leu and Ala541Thr (mutation) of HPC2/ELAC2 gene are not able to change enzymatic activities of ELAC2 and, also, indicated that these two variants are related to the prostate cancer in the samples of the men whose families are afflicted with hereditary prostate.