BCR and chronic myelogenous leukemia, BCR-ABL1 positive: The BCR-ABL encodes protein with aberrant ABL tyrosine kinase activity, which plays an essential role in CML pathogenesis (Deininger et al., 2000; Kantarjian et al., 2006; Jabbour et al., 2008; Chen et al., 2010; Alikian et al., 2017; Gale and Apperley, 2019).