A total of 12 case-control studies were included in this meta-analysis to find out the association of TP53 codon 72 Arg/Pro polymorphism with lung cancer and breast cancer in the South Asian population based on the inclusion criteria (Shabnaz et al., 2016; Hashemi et al., 2018; Aziz et al., 2013; Suresh et al., 2011; Syeed et al., 2010; Ihsan et al., 2011; Tilak et al., 2013; Chowdhury et al., 2015; Mostaid et al., 2014; Saikia et al., 2014; Sharma et al., 2014). This evidence concerns the gene TP53 and lung cancer.