DROSHA and neoplasm: So far, few tumor causing mutations have been reported in a few genes, frequently associated with molecular pathways involved in cell differentiation (such as CTNNB1, APC, WTX, and TP53, which are related to the Wnt signaling pathway4, 5, 6, 7; WT1, MYCN, and SIX1/2, which are critical for early renal development5, 8, 9, 10, 11) or posttranscriptional regulation (like the microRNA processor genes DROSHA, DICER1, XPO5, TARBP2, and DGCR89, 10, 11, 12, 13).