So far, few tumor causing mutations have been reported in a few genes, frequently associated with molecular pathways involved in cell differentiation (such as CTNNB1, APC, WTX, and TP53, which are related to the Wnt signaling pathway4, 5, 6, 7; WT1, MYCN, and SIX1/2, which are critical for early renal development5, 8, 9, 10, 11) or posttranscriptional regulation (like the microRNA processor genes DROSHA, DICER1, XPO5, TARBP2, and DGCR89, 10, 11, 12, 13). The gene discussed is TP53; the disease is neoplasm.