While the level of many circulating biomarkers increases with severity or worsening of heart failure, as is the case for e.g. the level of plasminogen activator inhibitor and tissue plasminogen activator antigen, both markers of fibrinolysis are elevated in heart failure patients across a wide range of LVEF, and regardless of LVEF.11, 13. The gene discussed is SERPINB2; the disease is heart failure.