From studies in GLUT9-deficient mice, it is known that the beneficial effects of lowering serum UA levels may be mainly regulated by enterocytes, since these mice develop impaired enterocyte uric acid transport kinetics, hyperuricemia, hyperuricosuria, spontaneous hypertension, dyslipidemia, and elevated body fat [45]. The gene discussed is SLC2A9; the disease is Hypertension.