Interestingly, fibroblast growth factor 21 (FGF-21), a circulating factor produced by hepatocytes that has been implicated to act protectively against insulin resistance and type 2 diabetes, mainly by enhancing glucose transport into adipose tissue, stimulates expression levels of hepatic GLUT1 and GLUT4, thereby also increasing glucose influx in an autocrine manner (Fig. 1). The gene discussed is FGF21; the disease is Insulin resistance.