On the other hand, Wat et al. [47] revealed that haploinsufficiency of Sox7 or Gata4 is sufficient to produce anterior CDH in mice and that haploinsufficiency of SOX7 and GATA4 may each contribute to the development of CDH in patients with 8p23.1 deletions. The gene discussed is GATA4; the disease is congenital diaphragmatic hernia.