Our data have highlighted a role for MFGE8 in mitochondrial tRNA aminoacylation, through its interactions with many aminoacyl t-RNA synthetases which could result in regulating tRNA maturation and proofreading, RNA splicing, amino-acid editing, and tmRNA aminoacylation protein synthesis36, resulting in regulating the shift from oxidative to glycolytic metabolism, prominent in cancer cells via activation of the PI3K–PTEN–AKT pathway36. Here, PTEN is linked to cancer.