AKT1 and cancer: Our data have highlighted a role for MFGE8 in mitochondrial tRNA aminoacylation, through its interactions with many aminoacyl t-RNA synthetases which could result in regulating tRNA maturation and proofreading, RNA splicing, amino-acid editing, and tmRNA aminoacylation protein synthesis36, resulting in regulating the shift from oxidative to glycolytic metabolism, prominent in cancer cells via activation of the PI3K–PTEN–AKT pathway36.