Following this framework, A (aggregated Aβ) and T (aggregated tau) define AD and can be measured using positron emission tomography (PET) or cerebrospinal fluid (CSF) biomarkers, while N (neuronal injury or neurodegeneration) is not specific to AD but provides staging of AD pathophysiological processes and can be measured using magnetic resonance imaging (MRI), [18F]FDG-PET, and CSF total tau (T-tau) [4]. Here, MAPT is linked to Alzheimer disease.