In AD Aβ+, both CSF and plasma NFL levels were significantly associated with VBM results in dorsal lateral frontal cortex, lateral temporal cortex, precuneus/PCC, medial frontal cortex, angular gyrus, hippocampus, and cerebellar grey in the voxel-based analyses (Fig. 5a, b and Supplementary Figs. 10 and 11 and Tables 10 and 11). This evidence concerns the gene NEFL and Alzheimer disease.