However, in folic acid-induced AKI and unilateral ureteral obstruction–induced renal fibrosis, blockade of MLKL, failed to protect against fibrogenesis or kidney injury while mice with RIPK3 deficiency showed reduced renal fibrosis and inflammatory response5,9, which indicates a necroptosis-independent role of RIPK3. This evidence concerns the gene MLKL and renal fibrosis.