For 9 out of 18 genes (IL6R, GUCY1A3, PHACTR1, TCF21, LPA, LPL, LIPA, PDGFD, ADAMTS7; 10 loci, LPA corresponds to the loci #21 and #22) we also obtained consistent evidence from SMR/HEIDI analysis, indicating that the effects of CAD-associated functional polymorphisms located in the loci containing these genes may be mediated by gene expression. The gene discussed is LPL; the disease is coronary artery disorder.