This may mean that either effect of rs3184504 on CAD is realized not/not only via altering the SH2B3 protein properties (for example, it can influence SH2B3 transcription or mediate RNA decay), or the locus #36 contains two functional CAD-associated SNPs in LD with each other – a missense SNP rs3184504 and another SNP affecting SH2B3 expression. Here, SH2B3 is linked to coronary artery disorder.