Our SMR/HEIDI analysis confirmed the role of 9 of these 18 genes (IL6R, GUCY1A3, PHACTR1, TCF21, LPA, LPL, LIPA, PDGFD, ADAMTS7), indicating that the same causal SNPs are associated with CAD and gene expression changes in CAD-relevant tissues. This evidence concerns the gene IL6R and coronary artery disorder.