Of the 9 genes listed above, AS3MT (locus #33), MAT2A (locus #10), SORT1 (locus #2), SRR (locus #46), and WDR12 (locus #12) were also proposed by some previous studies (Table 1, Supplementary Table S4), and the genes A4GNT (locus #13), IREB2 (locus #43), SH3PXD2A (locus #33), and SLC3A1 (locus #9), to the best of our knowledge, have never been suggested for CAD before. This evidence concerns the gene IREB2 and coronary artery disorder.