We suppose that besides undoubtedly causal genes LDLR and LPA, relevance for CAD is likely for the genes SLC22A3, SLC22A2, SLC22A1 (encoding organic cation transporters), PLG (encoding plasminogen involved in hemostasis), SMARCA4 (encoding a protein involved in vascular calcification52), and CARM1 (encoding methyltransferase involved in the control of stress-induced lipid metabolism53). This evidence concerns the gene LDLR and coronary artery disorder.