Focusing on angiosarcoma, we excluded that propranolol increased the response to docetaxel by inhibiting the P-gp-mediated transport of the chemotherapeutic agent; instead, our findings highlighted the impact that the expression of β-ARs might have on NF-kB/COX-2 signalling activation when taxane-based chemotherapy is planned and further confirmed the role of β-ARs in driving resistance to standard chemotherapy. Here, PGP is linked to angiosarcoma.