Because AS-O2 cells are slightly sensitive to docetaxel and exhibit constitutive activation of β-AR signalling that notoriously triggers pro-survival signals through NF-κB and Cox-2 signalling in several cancer types17, we hypothesized that propranolol enhanced the sensitivity of cells to docetaxel through the inhibition of the β-AR/NF-κB-COX-2 pathway. Here, ADRB2 is linked to cancer.