Among the 12 loci known to be related to PCOS, the 4 SNPs near LHCGR (rs10176989, OR = 0.78, P = 9.68 × 10−4), TOX3 (rs11075466, OR = 1.29, P = 1.73 × 10−4), RAB5B (rs705704, OR = 1.26, P = 2.47 × 10−3), and KHDRBS3 (rs10505648, OR = 0.59, P = 3.66 × 10−5) were significantly associated with PCOS. The gene discussed is KHDRBS3; the disease is polycystic ovary syndrome.