NPC1L1 and coronary artery disorder: The first and third quartiles (Q) of the CHD odds ratios (OR) per standard deviation (SD) in LDL-C for HMGCR, NPC1L1, PCSK9 (or HDL-C in the case of CETP) indicated modest variability in the point estimate: (Q1 1.61, Q3 1.78) for HMGCR, (Q1 1.42, Q3 1.77) for PCSK9, (Q1 1.19, Q3 1.68) for NPC1L1, and (Q1 0.87, Q3 0.91) for CETP. Between 95 and 99% of the estimates across all four genes were in the expected direction as inferred from the findings of drugs used in clinical trials to target the corresponding proteins19–25.