IL12B and inflammatory bowel disease: Consistent with this, genetically instrumented higher interleukin-12 subunit beta (encoded by IL12B) was associated with a higher risk of CD (OR 2.02; 95% CI 1.48, 2.76), UC (OR 1.56; 95% CI, 1.31, 1.87), and inflammatory bowel disease (IBD) (OR 1.56 95%CI 1.31, 1.87) (Fig. 6).