Among all 169 potential cancer drivers, 33 genes, including Notch1, Jup and Met, showed oncogenic features (Supplementary Fig. 3a), whereas the majority of genes, including Lipc, Cntn5, Hdac4, Nrxn3 and Cntnap5c, exhibited tumour suppressor features (Supplementary Fig. 3b). The gene discussed is NRXN3; the disease is neoplasm.