Genetic knockout and pharmacological blockade of TNFα, a proinflammatory cytokine also involved in regulating homeostatic plasticity (Steinmetz and Turrigiano, 2010; Stellwagen and Malenka, 2006), prevented noise-induced generation of tinnitus; conversely, TNFα administration caused tinnitus behavior in normal-hearing animals (Wang et al., 2019). Here, TNF is linked to Tinnitus.