ARC and Tinnitus: Decreased mobilization of Arc/Arg3.1, an activity-dependent cytoskeletal protein required for homeostatic synaptic plasticity in mouse primary visual cortex (Gao et al., 2010; Sedley et al., 2015), in the auditory cortex is associated with the development of tinnitus, but not hearing loss alone, following noise exposure (Rüttiger et al., 2013).