Functional analysis of DE lncRNAs of SHH MB subgroup using IPA predicts, MAX (a MYC interacting partner), miR-133a, FOLR1, E2F, ATF5, AM1, E2F3, GAS2L3 and ACSL5 as most significantly associated upstream regulators, while cancer, neurogenesis, cell proliferation, metastasis and cellular development are the most important biological functions affected in this subgroup (Tables 7 and 8). The gene discussed is ACSL5; the disease is cancer.