During the observation period in the current study, mortality was nearly three-times higher among individuals with COPD and hs-cTnI concentrations ≥5 ng/L and was more than four times higher in those with additional signs of ischemia on the electrocardiogram, compared to those without these biomarkers, even after adjusting for established cardiovascular risk factors. Here, TNNI3 is linked to chronic obstructive pulmonary disease.