In a recent study of 88 patients hospitalized for AECOPD with elevated hs-cTnI, coronary angiography detected ischemic heart disease in two-thirds, and half of these patients underwent percutaneous coronary intervention [28], supporting the assumption that, at least in this setting, elevated hs-cTnI is associated with subclinical ischemic heart disease. Here, TNNI3 is linked to coronary artery disorder.