EGFR and colorectal cancer: Currently, colorectal cancer is still a leading cause of cancer-related death worldwide.[1] Surgery remains mainstay of treatment for colorectal cancer, but for non-resectable tumors, chemotherapy, and targeted therapy are mostly used.[2] An example of the targeted therapy for colorectal cancer is anti-epithelial growth factor receptor (EGFR) therapy, e.g., cetuximab and panitumumab, which have been used for the treatment of metastatic colorectal cancer for more than 15 years.[3] However, those targeted therapies were plaqued by drug resistance.