We show that by altering the phosphorylation of p120-catenin by mutating six Serine and Threonine residues to Alanine that mimic the phosphorylation dead or dephosphorylated form of p120-catenin, we can enhance E-cadherin mediated cell adhesion in 4T1 metastatic tumor cells. The gene discussed is CDH1; the disease is metastatic neoplasm.