High expression of HIF1α in the hypoxic TME inhibits caveolin‐1 expression in tumour cells; a negative feedback mechanism up‐regulates the expression of the caveolin‐1‐related protein epidermal growth factor receptor, thereby activating the STAT3 signalling pathway and reducing the expression of epithelium‐specific markers.103. The gene discussed is STAT3; the disease is neoplasm.