M2 macrophages are activated by IL‐4 or IL‐13 ligands and notably polarized into M2a (anti‐inflammatory, tissue remodelling), M2b (Th2 activation, immunoregulation), M2c (phagocytosis of apoptotic cells), M2d (angiogenesis, tumour progression) subtypes, which are response for tumour progression and the main population of macrophages in TME.43 Here, IL4 is linked to neoplasm.