DRC5 and Reduced sperm motility: We have previously reported on genes whose KO led to asthenozoospermia, such as Tektin 3 (TEKT3) [11], Tektin 4 (TEKT4) [12], T-complex-associated-testis-expressed 1 (TCTE1) [13], and T-complex 11 (TCP11) [14], with each having unique roles in sperm motility.