Previous studies showed that TIPE1 could induce apoptosis in RAW264.7 cells or hepatocellular carcinoma cells by increasing the expression of Bcl‐2 family proteins or down‐regulating the Rac1 pathway,9, 10 and TIPE1 may also be a novel target capable of modulating tumorigenesis in gastric and lung cancer.11, 12. Here, RAC1 is linked to hepatocellular carcinoma.