Several mechanisms have been discussed to contribute to the excessive increase in BP during exercise, including aortic distensibility (Roman et al. 2007; Thijssen et al. 2016), endothelial dysfunction (Tzemos et al. 2009), and increased activation of the renin–angiotensin–aldosterone system (Schultz et al. 2013). This evidence concerns the gene REN and endothelial dysfunction.