MALAT1 and osteoporosis: Yang et al. (2019) recently described a similar role for MALAT1 (BM-MSC EVs) in the context of alleviating osteoporosis. Through binding to miR-34c, MALAT1 promoted the expression of a key protein required for osteogenic differentiation, SATB2, which is an expected target of miR-34c. Furthermore, treatment of human osteoblasts with MALAT1-containing EVs resulted in increased expression of Runx2 and ATF4 which are two proteins important for osteogenic differentiation. Thus, the pro-osteogenic functions of MSCs EVs were attributed to the sponging of miR-34c via MALAT1 (Yang et al., 2019).