BNIP3 and ductal breast carcinoma in situ: It is frequently found that the high expression of BNIP3 that occurs in many kinds of malignancies, such as salivary gland adenoid cystic carcinoma (Chen et al., 2015), endometrial cancer (Giatromanolaki et al., 2008), DCIS of breast and cervical cancer (Leo et al., 2006) is associated with the aggressiveness of the tumor and poor prognosis.