Recent studies indicated that the presence of TNF-α causes an upregulation of major catabolic enzymes involving Matrix-Metalloproteinases (MMPs) and A Disintegrin and Metalloprotease with Thrombospondin Motifs (ADAMTS), contributing to advanced structural decay in IDD (Purmessur et al., 2013; Tian et al., 2013; Baptista et al., 2020; Zhou et al., 2020). The gene discussed is TNF; the disease is intervertebral disk degenerative disorder.