TNF and intervertebral disk degenerative disorder: Both, Etanercept and Tofacitinib partially prevented the upregulation of proinflammatory cytokines in IVDs cultured under IDD-like conditions which supports outcome of previous in vitro studies on TNF-α inhibition (Likhitpanichkul et al., 2015; Walter et al., 2015b; Evashwick-Rogler et al., 2018).