Cross-linking immunoprecipitation (CLIP)-seq analysis was performed to identify mRNA sequences targeted by Roquin during HCMV infection and found an enrichment of previously known Roquin targets such as pro-inflammatory cytokine IL-6 and chemokine CXCL2, as well as novel targets including dickkopf WNT signaling pathway inhibitor 1 (DKK1) and interferon regulatory factor 2 binding protein like (IRF2BPL). Here, DKK1 is linked to cytomegalovirus infection.