TP53 and B-cell chronic lymphocytic leukemia: Recent data about the use of Chl-obinutuzumab (6, 16) in untreated CLL patients with comorbidities and the possible use of ibrutinib (17) in untreated CLL elderly patients (>65) who do not harbor del17p or TP53 mutation lead to further therapeutic options for CLL patients who are >65 years in age.