Previous studies have provided evidence about the expression of CDK1 and TOP2A in pancreatic cancer, but the correlation between them in pancreatic cancer has not been fully elucidated (Kalimutho et al., 2018; Li et al., 2017a; Shi et al., 2015; Xu et al., 2016). This evidence concerns the gene TOP2A and familial pancreatic carcinoma.