CDK1 and familial pancreatic carcinoma: Our results showed that among these hub genes, TOP2A is the most closely related gene to CDK1, TOP2A and CDK1, and it has been previously reported as a biomarker for pancreatic cancer (Kokkinakis, Liu & Neuner, 2005); however, to date, little attention has been paid to CEP55 and its possible relationship with CDK1.