A study has shown that apatinib inhibits the growth of osteosarcoma in vivo and in vitro, and induces the autophagy and apoptosis of osteosarcoma cells by directly inhibiting the expression of the anti-apoptotic protein Bcl-2 and inactivating signal transduction and activator of transcription 3 (STAT3)35. This evidence concerns the gene STAT3 and osteosarcoma.