EGFR and non-small cell lung carcinoma: In the present study, we demonstrated that combined treatment with a DYRK1A inhibitor and a Bcl-2 inhibitor produced a synergistic, anti-proliferative effect in EGFR wild-type NSCLC cell lines (NCI-H1299, A549, and NCI-H460) as well as in primary NSCLC cells (derived from three EGFR wild-type NSCLC patients and one patient with an EGFR exon 20 insertion mutation resistant to EGFR-TKI treatment; Table 1)36.