Our previous study showed that high expression of CUL4A and CUL4B was significantly associated with worse clinicopathological characteristics, including lymph node metastasis, higher tumor node metastasis stage, distant metastasis, and a larger tumor size in different subtypes of lung cancer, including squamous cell carcinoma (SCC), adenocarcinoma, large cell carcinoma, and small cell lung carcinoma (SCLC). This evidence concerns the gene CUL4B and lung cancer.