AKT3 and metastatic neoplasm: Although all three isoforms of AKT (AKT1, AKT2, and AKT3) have been reported to be expressed in both normal and CRC tissues45, AKT2 is more abundantly overexpressed in late-stage CRC and metastatic tumors, thus suggesting that AKT2 plays a critical role in CRC progression46 and may therefore be more susceptible to HSP47 inhibition.