The key signaling pathways and mechanisms involved in CRC include but are not limited to Wnt/APC/β-catenin, phosphoinositide 3-kinase (PI3K)/AKT/glycogen synthase kinase-3β (GSK-3β), Ras/Raf, NF-κB, transforming growth factor-β (TGF)-β/Smad, epithelial-to-mesenchymal transition (EMT), and mismatch repair genes. The gene discussed is NFKB1; the disease is colorectal carcinoma.