ABCC11 and breast carcinoma: This protein was previously shown to be responsible for the “wet earwax” syndrome in humans, due to a single nucleotide polymorphism48, and after the linking of this phenomenon to breast cancer, a study done in Japanese women found that the ABCC11 polymorphism (538 G mutant vs. 538A wild-type) was a risk factor for breast cancer development49, although other studies in populations with a different racial composition did not find this correlation50.