This transporter, a major cholesterol efflux pump, was shown to be down-regulated in mid- to high-grade prostate cancer in comparison to benign and non-tumor tissues, leading to intracellular accumulation of cholesterol, an important component of androgen synthesis in cells and in activation of the AKT signaling pathway, contributing to an environment conducive to tumor progression58. Here, AKT1 is linked to neoplasm.