However, in a coculture experiment involving AD-MSCs and NPCy undergoing high prolonged loading (3 MPa for 48 h), the presence of AD-MSCs resulted in a reduction on NPCy apoptosis via the inhibition of activated caspase-9 and 3 as well as in an upregulation of ECM genes with diminished expression of metalloproteinases and proinflammatory cytokines (IL-1β, IL-6, and TNF-α) [111]. This evidence concerns the gene CASP9 and Alzheimer disease.