We know that increased urinary AD7c-NTP levels are associated with tau-immunoreactive neurofibrillary tangles and amyloid-β (Aβ) deposition; similarly, the ApoE allele is also associated with hyperphosphorylated tau and Aβ deposition, which are the pathological hallmarks of AD [10, 27, 29, 30]. The gene discussed is APOE; the disease is Alzheimer disease.