IFNG and chronic myelogenous leukemia, BCR-ABL1 positive: In addition to the direct cytotoxic effect, the ability to generate IFN-γ producing effectors immediately and in large numbers allows the memory T cell transfer to exert a powerful GVL effect: IFN-γ sensitizes GVL-resistant blast crisis CML and acute myeloid leukemia to T cell-mediated killing (71).